Non-Small Cell Lung Cancer – COME HOME Regimens
CH LNG 1: Cis + etoposide
Cisplatin: 50 mg/m2 IV, days 1, 8, 29 and 36
Etoposide: 50 mg/m2 IV, days 1-5 and 29-33
with concurrent RT
CH LNG 2: Carbo + Pem
Carboplatin: AUC 5 IV, day 1, cycled every 21 days for 4 cycles
Pemetrexed: 500 mg/m2 IV, day 1, cycled every 21 days for 4 cycles
CH LNG 3: Cis + Pem
Cisplatin: 75 mg/m2 IV, day 1, cycled every 21 days for 3 cycles
Pemetrexed: 500 mg/m2 IV, day 1, cycled every 21 days for 3 cycles
CH LNG 4: Paclitaxel + Carbo
Paclitaxel: 175-200 mg/m2 IV, day 1, cycled every 21 days for 2 cycles
Carboplatin: AUC 6 IV, day 1, cycled every 21 days for 2 cycles
CH LNG 5: Paclitaxel + Carbo weekly
Paclitaxel: 50 mg/m2 IV, day 1 weekly
Carboplatin: AUC 2 IV, day 1 weekly
CH LNG 6: Cis + Vinblastine
Cisplatin: 100 mg/m2 IV, days 1 and 29
Vinblastine: 5 mg/m2 IV weekly, 1, 8, 15, 22 and 29 with concurrent RT
CH LNG 7: Cis + Vinorelbine
Cisplatin: 80 mg/m2 IV, day 1, cycled every 21 days for 4 cycles
Vinorelbine: 25-30 mg/m2, days 1 and 8, cycled every 21 days for 4 cycles
CH LNG 8: Cis + Vinorelbine weekly
Cisplatin: 50 mg/m2 IV, days 1 and 8, cycled every 28 days for 4 cycles
Vinorelbine: 25 mg/m2 IV, days 1, 8, 15 and 22, cycled every 28 days for 4 cycles
CH LNG 9: Cis + Gem
Cisplatin: 75 mg/m2 IV, day 1, cycled every 21 days for 4 cycles
Gemcitabine: 1250 mg/m2 IV, days 1 and 8, cycled every 21 days for 4 cycles
CH LNG 10: Cis + Docetaxel
Cisplatin: 75 mg/m2 IV, day 1, cycled every 21 days for 4 cycles
Docetaxel: 75 mg/m2 IV, day 1, cycled every 21 days for 4 cycles
CH LNG 11: Paclitaxel weekly
Paclitaxel: 80 mg/m2 IV, day 1 weekly
CH LNG 12: Docetaxel + Carbo
Docetaxel: 75-80 mg/m2 IV, day 1, cycled every 21 days
Carboplatin: AUC 5-6 IV, day 1, cycled every 21 days
CH LNG 16: Pemetrexed Maintenance
Pemetrexed: 500 mg/m2 IV, day 1, cycled every 21 days
CH LNG 17: Bevacizumab maintenance
Bevacizumab: 7.5 mg/kg IV, day 1, cycled every 21 days
CH LNG 18: Erlotinib
Erlotinib: 150 mg, daily
CH LNG 19: Afatinib
Afatinib: 40 mg PO, daily
CH LNG 20: Crizotinib
Crizotinib: 250 mg PO q12hr,
CH LNG 21: Ceritinib
Ceritinib: 750 mg PO, daily
CH LNG 22: Carbo + gem
Carboplatin: AUC 5-6 IV, day 1, cycled every 21 – 28 days for 4 cycles
Gemcitabine: 1000-1250 mg/m2 IV, days 1 and 8, cycled every 21 – 28 days for 4 cycles
CH LNG 23: Erlotinib maintenance
Erlotinib: 150 mg, daily
CH LNG 24: Docetaxel
Docetaxel: 75-80 mg/m2 IV, day 1, cycled every 21 days
CH LNG 25: Pemetrexed
Pemetrexed: 500 mg/m2 IV, day 1, cycled every 21 days
CH LNG 26: Gemcitabine
Gemcitabine: 1000-1250 mg/m2 IV, days 1 and 8, cycled every 21 days
CH LNG 27: Vinorelbine
Vinorelbine: 25 mg/m2, weekly
CH LNG 28: Carboplatin + Paclitaxel +/- Bev
Carboplatin: AUC 6 IV, day 1, cycled every 21 for 6 cycles
Paclitaxel: 200 mg/m2 IV, day 1, cycled every 21 days for 6 cycles
Bevacizumab: 15 mg/kg, day 1, cycled every 21 days until progression
CH LNG 29: Cisplatin + Paclitaxel
Cisplatin: 70 mg/m2 IV, day 1, cycled every 21 days for 4 cycles
Paclitaxel: 175 mg/m2 IV, day 1, cycled every 21 days for 4 cycles
CH LNG 30: Nivolumab
Nivolumab 240 mg IV, every 14 days
CH LNG 31: Pembrolizamab + Chemo
Pembrolizamab 200 mg IV day 1, 21 day cycles
CH LNG 32: Atezolizumab
Atezolizumab: 1200 mg IV, every 3 weeks