Pancreatic Cancer – COME HOME Regimens
CH PANC 1: FOLFIRINOX
Irinotecan (Camptosar) 180 mg/m2 IV day 1
Oxaliplatin (Eloxatin) 85 mg/m2 IV day 1
Leucovorin 400 mg/m2 IV day 1
5-FU 400 mg/m2 IV day 1
5-FU CIVI 2400 mg/m2 over 46 hrs
CH PANC 2: GEM + XRT
MCCM Protocol from Annals of Surgical Oncology 2006, see next page
CH PANC 3: 5FU + XRT
5FU 225 mg/m2/day 5-7 days per week
XRT 5-7 days per week for 5 weeks
CH PANC 4: Capecitabine + XRT
Capecitabine 825 mg/m2 BID 5 days/week
XRT 5-7 days per week for 5 weeks
CH PANC 5: GEM – 5FU/XRT – GEM
Gemcitabine 500-1000 mg/m2 IV weekly x 3 weeks
Then (1-2 weeks later):
5-FU 225 mg/m2/day CIVI during XRT for 42 days
Then:
Gemcitabine 500-1000 mg/m2 IV days 1, 8, 15
Every 28 days x 3 cycles
CH PANC 6: Gemcitabine
1000 mg/m2 days 1, 8, 15, every 28 days
CH PANC 7: 5FU/Leucovorin
Leucovorin 500 mg/m2 day 1, 8, 15, 22, 29, 36
5FU 500 mg/m2 day 1, 8, 15, 22, 29, 36
CH PANC 8: Gemcitabine + nab-Paclitaxel
Gemcitabine 1000 mg/m2/day day 1, 8, 15
nab-Paclitaxel 125 mg/m2 day 1, 8, 15
Cycled every 28 days
CH PANC 9: FOLFOX
Oxaliplatin 85 mg/m2 IV day 1
Leucovorin 400 mg/m2 IV day 1
5-FU 400 mg/m2 IV day 1
5-FU CIVI 2400 mg/m2 over 46 hrs
CH PANC 10: CapeOX
Oxaliplatin 130 mg/m2 IV day 1
Capecitabine 1000 mg/m2 BID oral days 1-14
Cycled every 21 days
CH PANC 11: GEM – Cape/XRT – GEM
Gemcitabine 500-1000 mg/m2 IV weekly x 3 weeks
Then (1-2 weeks later):
Capecitabine 825 mg/m2 BID during XRT for 42 days
Then:
Gemcitabine 500-1000 mg/m2 IV days 1, 8, 15
Every 28 days x 3 cycles
CH PANC 12: Pembrolizamab + Chemo
Pembrolizamab 200 mg IV day 1, 21 day cycles
Ann Surg Oncol. 2006 Feb;13(2):150-8. Epub 2006 Jan 19.A multi-institutional phase II trial of preoperative full-dose gemcitabine and concurrent radiation for patients with potentially resectable pancreatic carcinoma.
FIG: Treatment schema of full-dose gemcitabine (1000 mg/m2) and concurrent radiation (36 Gy in 2.4-Gy fractions). Gemcitabine was administered on days 1 and 8 of a 21-day cycle before and after a 28-day cycle of gemcitabine on days 1, 8 and 15, and concurrent radiation on days 1 to 19. XRT, radiotherapy.